Research in the Ron-Harel lab focuses on T cell immunometabolism and aging. T lymphocytes play a central role in the immune defense against intruders, and support tissue homeostasis and function. An aged or dysfunctional T cell immunity is sufficient to promote organ aging and multiple age-related morbidities. We investigate the other direction of this interaction, to define how the in vivo microenvironment in the aged host dictates T cells aging trajectories.