In our lab we challenge basic dogmas regarding inheritance and evolution, using simple powerful genetic model organisms. In particular, using nematodes, we have shown that exposure to different challenges triggers the synthesis of heritable small RNAs which regulate genes in the progeny, resulting in phenotypic changes several generations down the road. In addition to studying epigenetic inheritance, we are developing useful parasites, investigating the neuronal basis of rational decision-making, and try to do as many crazy experiments as possible.