Adenosine-to-inosine (A-to-I) mRNA editing alters the genetic information at the RNA level. Subsequently, A-to-I mRNA editing can affect proteins’ sequence and function because the ribosome identifies inosine as guanosine.

Previously, we discovered that mRNA editing occurs in bacteria, identified the mediating enzyme, and showed that mRNA editing affects protein function and bacterial growth.

Our goal is to identify mRNA editing events across the bacterial species and reveal their importance for bacterial biology and human health.