We study musculoskeletal development and skeletal regulation by proprioception. We have recently discovered that the enthesis, connecting between tendon and bone, is formed by a unique population of bi-fated cells. We seek to determine the location of these cells and how their unique fate is regulated, both molecularly and by mechanical signals. We have also found recently that impaired proprioceptive signaling results in skeletal pathologies, such as scoliosis and DDH. We explore the molecular mechanisms underlying proprioceptive function during development, regeneration and aging.
ERC Consolidator Research Grant 2012
Prize in Biology awarded by the Scientific Council, Weizmann Institute of Science