Most mammals encounter frequent and prolonged bouts of fasting. Intricate mechanisms evolved to maintain homeostasis during fasting. The liver plays a central role in the response to fasting.
Our lab investigates how chromatin and transcription factors regulate the fasting response. Using genomic, metabolic and molecular biology approaches, we study the gene regulatory networks that mediate the liver’s response to fasting. We aim to better understand these transcriptional networks and how their dysregulation can contribute to obesity, diabetes and non alcoholic fatty liver disease (NAFLD).
ERC starting grant
Israel Science Foundation