The Berman lab studies drug response mechanisms in pathogenic yeasts due to genetic mutations, genomic copy number shifts, and physiological processes such as metabolic and proteomic shifts. Using interdisciplinary approaches, we identify fundamental connections between morphogenesis, chromosome stability, chromatin-mediated silencing, gene essentiality, and drug responses. Together with the Ralser lab, we study antifungal drug tolerance, the ability of some cells to grow slowly while other genetically identical cells are inhibited, a clinically relevant mechanism of phenotypic heterogeneity.