Our pioneering work centers on the communication mechanisms of the parasite through the secretion of extracellular vesicles (EVs) and their contents, which comprise an array of bioactive molecules, such as proteins, lipids, glycans, RNA, and DNA. This is a relatively new area of malaria research and only little is currently known about EV cargo delivery as well as functions, in particularly in mediating pathogen-host interaction. By delving into the cellular mechanisms that the parasites employ, we unlocked the mystery of how they communicate with their two different host systems.