The goal of my research is to achieve a better understanding of the evolutionary selection forces shaping genes and genomes, and to develop in-silico methods for their inference. I strive to harness the dramatic increase in available genomic sequences and protein three-dimensional structures, with advanced evolutionary based models, for functional genomics predictions. Novel bioinformatics methods based on advanced evolutionary models, statistical tools, and structural-based methods are developed in my lab to enable maximal extraction of information from these raw data.