We investigate the implication of oxidative stress and free radicals production from epileptogenic phase through the establishment of epilepsy in experimental models. Our lab seeks to develop antioxidant therapies by elucidating several modulatory targets including genes and proteins towards the development of therapeutic treatment for refractory epilepsy. We employs a multidisciplinary experimental approaches including molecular biology, gene therapy, live cell imaging, electrocorticography (ECoG) seizure monitoring in animal models, and in vivo live imaging in freely behaving animals.