Our lab focuses on a unique, understudied trait of cancer. Changes in the chromosomal composition of the cell, also known as aneuploidy, make for a fundamental difference between normal and cancer cells. We combine experimental and computational approaches to uncover the basic biology underlying this hallmark of cancer, track its origins and understand its cellular consequences. By doing so, we strive to expand our understanding of the genetic basis of cancer, and to make aneuploidy a therapeutic target for precision cancer medicine.